Should proton pump inhibitors be withheld from patients taking clopidogrel? The issue that has been giving me heartburn!
نویسنده
چکیده
منابع مشابه
Managing gastroesophageal reflux disease – comparative efficacy and outcomes of dexlansoprazole MR
The management of gastroesophageal reflux disease (GERD) has been revolutionized with the development of proton pump inhibitors (PPIs). Unfortunately, due to the inherent pharmacokinetic and pharmacodynamic profiles of conventional PPIs, many patients continue to suffer from symptoms related to GERD despite appropriate use of PPIs. Dexlansoprazole MR is a PPI with a unique dual delayed-release ...
متن کاملInteraction between clopidogrel and proton pump inhibitors.
The drug interaction between proton pump inhibitors and clopidogrel has been the subject of much study in recent years. Contradictory results regarding the effect of proton pump inhibitors on platelet reactivity and on clinical outcome in clopidogrel-treated patients have been reported in literature. Concomitant use of omeprazole and clopidogrel was found to decrease the exposure (AUC) to clopi...
متن کاملAntiplatelet agents and proton pump inhibitors – personalizing treatment
INTRODUCTION Antiplatelet therapy remains one of the cornerstones in the management of non-cardioembolic ischemic stroke. However, a significant percentage of patients have concomitant gastroesophageal reflux or peptic ulcer disease that requires acid-reducing medications, the most powerful and effective being the proton pump inhibitors (PPIs). Antiplatelet efficacy, at least in vivo, and parti...
متن کاملCurrent standings of the proton pump inhibitor and clopidogrel co-therapy: review on an evolving field with the eyes of the gastroenterologist.
The negative effect of proton pump inhibitors (PPI) on the antiplatelet function of clopidogrel has only recently emerged on the horizon of cardiological interest. To date, one can only find 10 peer-reviewed papers on PubMed on this issue, although the increasing activity is unquestionable. Besides publications, conference reports and official web sites are therefore important sources of inform...
متن کاملTreatment with clopidogrel and proton pump inhibitors in combination: a review of emerging evidence
Proton pump inhibitors often are prescribed in combination with clopidogrel to decrease risk of gastrointestinal bleeding after acute coronary syndrome. Clopidogrel is a prodrug that has to be metabolized in the liver to generate the active metabolite. Both medications are metabolized largely by the CYP2C19 enzyme; therefore, concerns exist that a drug-drug interaction during concomitant treatm...
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عنوان ژورنال:
- Circulation. Cardiovascular quality and outcomes
دوره 8 1 شماره
صفحات -
تاریخ انتشار 2015